Spinal cord compression as the first presentation of non-Hodgkin’s lymphoma is a rare entity. In this paper, we presented a patient with disseminated non-Hodgkin’s lymphoma initially presenting with progressive severe weakness and paresthesia of his legs and walking difficulty with a 5-month history of back pain. Imaging findings of vertebral non-Hodgkin’s lymphoma were also described with its associated pancreatic, renal and bilateral adrenal gland involvements.

Keywords: Non-Hodgkin’s lymphoma, spinal cord compression, magnetic resonance imaging, vertebral involvement