Cerebrospinal fluid (CSF) fistula is an important complication in neurosurgery. A literature review was performed with the use of Hemopatch® in cranial surgery together with fibrin glue. Early and late postoperative results of 4 patients who were operated for an intracranial mass and used Hemopatch® with fibrin glue in the dural closure of CSF leak stage were evaluated. The mean age of the patients was 62.25 ± 10.49 years and the mean follow-up period was 16.25 ± 3.27 weeks. All of the patients who used fibrin glue Hemopatch® consisted of patients who had undergone cranial surgery (75% was pterional craniotomy, 25% was retrosigmoid craniotomy). Cerebrospinal Fluid (CSF) leakage occurred in the early post-operative period in 1 patient who underwent Hemopatch® by completely removing the dural layer due to extensive dural invasion and performing duraplasty with fascia after the follow-up. Hemopatch was applied and CSF leakage was not observed in the other 3 patients with small dural defects. In conclusion, we first demonstrated the feasibility and safety of using Hemopatch® as a dural sealant in fibrin glued cranial surgery.

Keywords: CSF fistula, dural closure, hemopatch