Parkinson’s disease (PD) is the second most common progressive neurodegenerative, besides a minority of genetic cases, underlying etiopathophysiology is still unknown. Currently, no proven and exact treatment has existed. It is crucially important to develop reliable animal models that might be used for the screening and testing of new therapeutic strategies e.g., stem cell transplantation targeting the actual pathogenic process as opposed to merely developing symptomatic therapies. Here, we summarized the updated in vivo and in vitro models of PD and reviewed the stem cell-based experimental studies by using these models.

Keywords: Animal model, Parkinson’s disease, stem cell transplantation