Glioblastoma multiforme (GBM) is the most malignant and aggressive brain tumor. This type of glial tumors usually tend to develop local recurrences, however, distant intracranial metastasis rarely reported in the literature. Herein, the authors present a 52-year-old male patient who presented with right hemiparesis, nausea and vomiting. His MRI demonstrated the presence of a left parietal mass. The patient was managed using stereotactic surgical procedure. Postoperative MRI confirmed that gross-total resection was performed. Twenty-one months later, the patient was presented again with dysarthria, unsteady gait, and generalized seizure. New MRI revealed a left frontal mass, without local relapse to left parietal mass. The patient underwent second operation to remove left frontal mass. The two mass excised were diagnosed as GBM (WHO grade IV). Despite the attention was given to protect CSF cisterns from the removed mass using stereotactic guide in the first surgery, distant metastases developed. The patient died four months after second surgery related to respiratory infection.

Keywords: Glioblastoma multiforme, distant intracranial metastasis, neuraxis dissemination