Genomic alterations and molecular mechanisms in the etiopathogenesis of Cushing’s Syndrome
Keywords:Cushing, ACTH, Pituitary Adenoma
The pituitary gland is a 5-7 mm-sized gland that controls the secretion of many different hormones in the body. Pituitary tumors, most of which are benign (pituitary adenomas), may occur as a result of the interaction of different types of cells hosted by the pituitary gland with various genetic, epigenetic and environmental factors. Difficult to diagnose and treatof these pituitary adenomas is Cushing’s disease, which occurs as a result of excessive secretion of cortisol. It is known that Cushing’s disease occurs due to the loss of function of many different genes such as USP8, USP48, EGFR, p16, p21. In addition, Cushing’s disease is seen as a result of exposure to various epigenetic modifications such as methylation and acetylation of related genes and various regulators such as miRNAs. By determining the functions of these genes and proteins, new treatment strategies will be developed and diagnosis and treatment of pituitary tumors will be facilitated.