Frontal Meningioma After Postoperative Cranial Irradiation for Posterior Fossa Medulloblastoma

Abstract

The development of cranial neoplasms subsequent to therapeutic radiation therapy (RT) is a rare entity but a serious complication. Radiation induced meningiomas are late complications in patients who have received high dose irradiation for brain tumors and the most common form of radiation-induced neoplasm. Radiation- induced meningiomas occuring after treatment of a medulloblastoma are rarely seen. We present a case of a 21-year-old male with frontal meningioma developed after 13 years from neuroaxis radiation therapy for medulloblastoma. Surgical resection and RT was applied for our patient at the age of 8 due to medulloblastoma. At age 21, the patient noted gradual onset of frontal headaches. A neurological examination at that time did not reveal any focal neurologic deficits. Magnetic resonance imaging demonstrated a left frontal mass. The patient underwent left frontal craniotomy and the mass removed totally. Histopathological examination revealed a meningotheliomatous meningioma.