Stem Cell Therapies For Neurological Diseases

Authors

  • Haluk Deda Deda Brain and Spine Center

Keywords:

bone marrow, stem cell, therapy, neurological disease

Abstract

Cells of the central nervous system were once thought to be incapable of regeneration. This dogma has been challenged in the last decade with studies. There are reports of bone marrow derived cells developing neuronal and vascular phenotypes and aiding in repair of injured brain. These findings ave fuelled excitement and interest in regenerative medicine for neurological disease. These include cell therapy approaches in which cells are delivered intracerebrally or intraspinally and these cells are infused by an intravenous or intraarterial route. Stem cell and regenerative approaches to neurological disease can be divided into a number of categories depending upon the target neurological disease. Neuronal tissue injury involves destruction of multiple cell types. Therefore, the regenerative strategy will need to restore not only neural elements but supportive structures such as blood vessels. The mechanism of the benefit of cell therapies upon neurological function involves trophic and stimulating effects on endogenous neurones, astrocytes and blood vessels. This trofic effect appears to be a characteristic of stem cells. Endogenous repair processes is the best target for therapy. The effevtiveness of cell therapy will be more related to the capacity to secrete trophic and growth factors and an antiinflammatory effect rather than by ability to differentiate into neurones and integrate directly into a complex nervous system. My results of stem cell therapy is an effective and promising procedure for neurological disease.

Downloads

Download data is not yet available.

Published

2008-09-30

How to Cite

1.
Deda H. Stem Cell Therapies For Neurological Diseases. J Nervous Sys Surgery [Internet]. 2008 Sep. 30 [cited 2024 Mar. 28];1(3):142-5. Available from: https://sscdergisi.org/index.php/sscd/article/view/107

Issue

Section

Review