Targeted Treatment for Glioblastoma: Evaluation of Available Strategies and Novel Targets

Authors

  • Zübeyde Erbayraktar Dokuz Eylul University, Faculty of Medicine, Department of Biochemistry, Izmir, Turkey.
  • Serhat Erbayraktar Dokuz Eylul University, Faculty of Medicine, Department of Neurosurgery, Izmir, Turkey.
  • Erdoğan Pekcan Erkan University of Helsinki, Medicum, Department of Medical Genetics, Helsinki, Finland.

DOI:

https://doi.org/10.5222/sscd.2015.059

Keywords:

Glioblastoma, targeted treatment, single cell, tumor heterogeneity

Abstract

Studies aiming to reveal genetic profiling of glioblastoma have enabled to identify different molecular subtypes of the tumor, while analyses performed at single cell level have revealed the cell populations within the tumors having distinct genetic structures. These factors constitute “the intrinsic resistance” possessed by the tumor, and limit the efficacy of available treatment options. In this review, we revisit glioblastoma biology from a molecular perspective, and try to highlight novel molecular targets, which can be utilized to develop new targeted treatments with higher efficacy.

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Published

2015-12-30

How to Cite

1.
Erbayraktar Z, Erbayraktar S, Erkan EP. Targeted Treatment for Glioblastoma: Evaluation of Available Strategies and Novel Targets. J Nervous Sys Surgery [Internet]. 2015 Dec. 30 [cited 2024 Apr. 25];5(2):59-68. Available from: https://sscdergisi.org/index.php/sscd/article/view/35

Issue

Vol. 5 No. 2 (2015)

Section

Review