Neuroprotective Effect of ACE Inhibitors Following Cerebral Ischemia in Rats: Histopathological Evaluation

Authors

  • Süleyman Coşkun Departments Of Neurosurgery, Ataturk University, Erzurum, Turkey.
  • Gökşin Şengül Departments Of Neurosurgery, Ataturk University, Erzurum, Turkey.
  • Murteza Çakır Departments Of Neurosurgery, Ataturk University, Erzurum, Turkey.
  • Ahmet Hacımüftüoğlu Departments Of Pharmacology, Ataturk University, Erzurum, Turkey.
  • Fatih Saruhan Departments Of Pharmacology, Ataturk University, Erzurum, Turkey.
  • Mustafa Kemal Çoban Departments Of Neurosurgery, Ataturk University, Erzurum, Turkey.
  • Muhammet Çalık Departments Of Pathology, Ataturk University, Erzurum, Turkey.

Keywords:

ACE inhibitors, neuron, neuroprotective effects, cerebral ischemia

Abstract

Objective: Angiotensin converting enzyme (ACE) inhibitors are frequently used in the treatment of essential hypertension causing disorders especially in the cerebral circulation. In this study, neuroprotective effect, and mechanism of action of ACE inhibitors in focal cerebral ischemia created in rats via unilateral common carotid artery ligation were examined and their effects on behavior patterns were tested.

Methods: Thirty rats were used in this study. The rats were separated into 5 groups randomly. Following left common carotid artery ligation, Group 1 was given captopril, Group 2 ramipril, and Group 3 perindopril. Group 4 received normal saline for 7 days, and Group 5 was used as a control group. The rats were sacrificed after carrying out behavioral tests for 7 days. Their exenterated brains were histopathologically examined.

Results: Neuronal damage was lower in ACE inhibitor groupa in comparison to the normal saline group The lowest neuronal damage was observed in the perindopril group. The results of behavioral tests indicated that ACE inhibitors did not have any effect on behavior patterns in cerebral ischemia.

Conclusions: Our data indicate that perindopril, ramipril and captopril have beneficial effects in brain ischemia and should be tried as therapeutic agents in the management of this condition.

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Published

2010-12-30

How to Cite

1.
Coşkun S, Şengül G, Çakır M, Hacımüftüoğlu A, Saruhan F, Çoban MK, Çalık M. Neuroprotective Effect of ACE Inhibitors Following Cerebral Ischemia in Rats: Histopathological Evaluation. J Nervous Sys Surgery [Internet]. 2010 Dec. 30 [cited 2024 Apr. 25];3(2):66-71. Available from: https://sscdergisi.org/index.php/sscd/article/view/156

Issue

Vol. 3 No. 2 (2010)

Section

Research Article